Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice
نویسندگان
چکیده
منابع مشابه
Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice.
Midbrain dopaminergic (mDA) neurons control movement and emotion, and their degeneration leads to motor and cognitive defects in Parkinson's disease (PD). miR-133b is a conserved microRNA that is thought to regulate mDA neuron differentiation by targeting Pitx3, a transcription factor required for appropriate development of mDA substantia nigra neurons. Moreover, miR-133b has been found to be d...
متن کاملNeurobiology of Disease Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice
Mary P. Heyer,1,2 Amar K. Pani,3 Richard J. Smeyne,3 Paul J. Kenny,2 and Guoping Feng1,4 1Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, 2Laboratory of Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics, The Scripps Research Institute Florida, Jupiter, Florida 33458, 3Department of Developmental Neurobiology, St. Jude Children’...
متن کاملMorphine regulates dopaminergic neuron differentiation via miR-133b.
Morphine is one of the analgesics used most to treat chronic pain, although its long-term administration produces tolerance and dependence through neuronal plasticity. The ability of morphine to regulate neuron differentiation in vivo has been reported. However, the detailed mechanisms have not yet been elucidated because of the inability to separate maternal influences from embryonic events. U...
متن کاملTranscriptional control of midbrain dopaminergic neuron development.
Although loss of midbrain dopaminergic neurons is associated with one of the most common human neurological disorders, Parkinson's disease, little is known about the specification of this neuronal subtype. Hence, the recent identification of major transcriptional determinants regulating the development of these neurons has brought much excitement and encouragement to this field. These new findi...
متن کاملGenetic and epigenetic control of midbrain dopaminergic neuron development.
The relatively few dopaminergic (DA) neurons in the mammalian brain regulate many important neural functions, including motor integration, neuroendocrine hormone release, cognition, emotive behaviors and reward. A number of laboratories, including ours, have contributed to unravel the mechanisms of DA phenotype induction and maturation and elucidated the role of epigenetic factors involved in s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1732-12.2012